The ATXN3 Antibody, Biotin conjugated from MyBioSource.com is a Rabbit Polyclonal antibody to Ataxin 3, and ATXN3. This antibody recognizes Human antigen. The ATXN3 Antibody, Biotin conjugated has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. In response to misfolded substrate ubiquitination, mediates deubiquitination of monoubiquitinated STUB1/CHIP. Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription